Table 1:
IMWG and R-MCI classification of elderly MM patients according to fitness profile and frailty score
| IMWG frailty score (2015) | ||
|---|---|---|
| Parameter | IMWG-frailty index points | |
| Age (years) | ≤75 | 0 |
| 76- 80 | 1 | |
| >80 | 2 | |
| ADL | >4 | 0 |
| ≤4 | 1 | |
| IADL | >5 | 0 |
| ≤5 | 1 | |
| CCI | ≤1 | 0 |
| >1 | 1 | |
| Patient status | Cumulative IMWG frailty score | |
| Fit | 0 | |
| Intermediate-fit | 1 | |
| Frail | 2-5 | |
| R-MCI (2016) | ||
| Parameter | R-MCI points | |
| Age (years) | <60 | 0 |
| 60-69 | 1 | |
| ≥ 70 | 2 | |
| KPS | 100% | 0 |
| 80-90% | 2 | |
| <70% | 3 | |
| eGFR (ml/min) | ≥60 | 0 |
| <60 | 1 | |
| Frailty* | Mild | 0 |
| Moderate/Severe | 1 | |
| Cytogenetics | Missing | 0 |
| Favorable** | 0 | |
| Unfavorable*** | 1 | |
| Lung dysfunction | No/Mild | 0 |
| Moderate/Severe | 1 | |
| Patient status | Cumulative R-MCI frailty score | |
| Fit | 0-3 | |
| Intermediate-fit | 4-6 | |
| Frail | 7-9 | |
Abbreviations: ADL= Activities of daily life; CCI= Charlson Comorbidity Index; IADL= Instrumental activities of daily living; IMWG= International Myeloma Working Group; KPS Karnofsky Performance Status; R-MCI= Revised Myeloma Comorbidity Index.
*
Parameters: Karnofsky Index, Time Up/Go, IADL, Subjective fitness.
**
Hyperdiploidie, t(11; 14), NK, del(13q14)
***
t(4,14), t(14,16), t(14,20), del(17p), Hypodiploidie, c-myc, Chromosom1-aberrations