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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Hypertension. 2019 Jun;73(6):1308–1318. doi: 10.1161/HYPERTENSIONAHA.118.12437

Figure 3. Maternal plasma circulating proteasome profile analyzed by principal component analysis.

Figure 3.

(A) Scatterplot of the first two principal components (PC1 and PC2) that explain 90% of the variance in the data. This analysis revealed that women with preeclampsia without severe clinical feature (mPE, n=10), preeclampsia with severe clinical features (sPE, n=39), and women with hemolysis, elevated liver enzymes, and thrombocytopenia (HELLP syndrome, n=16) co-cluster along a different trajectory from idiopathic spontaneous preterm birth (sPTB, n=21), chronic hypertension (crHTN, n=25), and gestational hypertension (gHTN, n=25). Pregnant controls (P-CRL, n=14) are closely grouped near the graph’s origin. Bar graphs (mean and standard error) of (B) PC1 and (C) PC2 for each clinical group with statistical significance. 1-way analysis of variance followed by multiple comparisons with Holm-Sidak method. * P<0.05, ** P<0.01, *** P<0.001 vs P-CRL group.