1. Results of individual study.

Study ID	Dose of lidocaine	Comparator	Number of participants	Withdrawals	Efficacy	Adverse events (intervention)	Adverse events (placebo)
Wasiak 2011	Initial bolus dose of lidocaine 1.5 mg/kg/body weight followed by 2 boluses of 0.5 mg/kg/body weight at 5‐minute intervals and an infusion run at 2 mg/minute throughout duration of dressing	0.9% NaCl (normal saline) at equivalent dose, rate and volume as intervention	45	The authors reported no loss to follow‐up of participants for primary outcome measures	Verbal rating scale scores lower for lidocaine compared with placebo. No difference between groups in time to rescue analgesia, opioid requests and consumption using patient‐controlled analgesia, and overall participant anxiety and level of satisfaction	Pre‐dressing: twitchiness 1/45 and nausea/vomiting 8/45 Dressing: twitchiness 1/45 and nausea/vomiting 5/45 Post‐dressing: nausea/vomiting 8/45	Pre‐dressing: nausea/vomiting 2/45 Dressing: nausea/vomiting 4/45 and severe pain 1/45 Post‐dressing: nausea/vomiting 4/45