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. Author manuscript; available in PMC: 2020 Mar 27.
Published in final edited form as: J Am Chem Soc. 2019 Mar 13;141(12):5051–5061. doi: 10.1021/jacs.9b01693

Figure 6.

Figure 6.

Overview of the propylamycin 5 (CMP5) binding site (yellow) on the T. thermophilus 30S subunit (A) and 70S ribosome (B) (PDB ID 6O97). The 30S and 50S subunits are, respectively, light and dark grey. mRNA is shown in blue and tRNAs are displayed in green for the A site, in magenta for the P site, and in orange for the E site. In (A), the 30S subunit is viewed from the subunit interface, as indicated by the inset; the 50S subunit and parts of tRNAs are removed for clarity. (C, D) Close-up views of the AGA canonical binding site showing the interactions of 5 with the 16S rRNA.