. Author manuscript; available in PMC: 2020 Mar 27.

Published in final edited form as: J Am Chem Soc. 2019 Mar 13;141(12):5051–5061. doi: 10.1021/jacs.9b01693

Table 5.

Activity of Propylamycin 5 and Clinical Comparators in the Presence of Multiple Resistance Determinants (μg.mL⁻¹)

	Isolate	Resistance Mechanism	Propylamycin	Gentamicin	Tobramycin	Amikacin
E. coli	2014405344	AAC(3), APH(3’), RmtB	4	>256	>256	>256
	201430298	AAC(3), AAC(6’)	1	128	256	8
	2014251408	AAC(3), AAC(6’)	2	256	128	64
	201441114	AAC(6’), ANT(2’’)	1	16	32	64

K. pneumoniae	2014310108	AAC(3), AAC(6’), RmtB	1	>256	>256	>256
	201440494	AAC(3), AAC(6’)	0.5	32	16	2
	2014310114	AAC(3), AAC(6’)	0.25	256	256	8

E. cloacae	201385168	AAC(3), AAC(6’), RmtC	1	>256	>256	>256
	201333207	AAC(3), AAC(6’), APH(3’)	0.5	64	32	16
	201435487	AAC(3), AAC(6’)	0.5	64	16	4
	201430601	AAC(6’), ANT(2’’)	0.5	16	32	8