Table 2. Areas significantly responded to sound omission or correlated to other measures.
Region (BA) | Talairach coordination (X, Y, Z) of peak location | p-value (FWE corrected, cluster level) |
t-value (peak level) | Number of significant voxels |
---|---|---|---|---|
Areas significantly responding to omission of sound in controls (Fig 4). | ||||
Lt. superior temporal gyrus (BA 41) | (-59.4, -26.8, 8.7) | 0.033 | 5.25 | 84 |
Areas with reduced BOLD activity in the left middle temporal gyrus in patients 8 (Fig 5). | ||||
Lt. middle temporal gyrus (BA 39) | (-37,6–72.9, 18.4) | 0.003 | 5.35 | 231 |
Areas where BOLD activity significantly correlated positively with MMN amplitude at the Fz site in patients (Fig 6). | ||||
Rt. superior temporal gyrus (BA 42) | (57.4, -32.5, 10.8) | 0.018 | 6.85 | 103 |
Areas where BOLD activity significantly correlated positively with PANSS scores of positive symptoms (Fig 7) | ||||
Rt. parahippocampal gyrus (BA 19) | (41.6, -42.6, 2.1) | 0.000 | 8.32 | 392 |
Areas where BOLD activity significantly correlated positively with PANSS scores of hostility and Positive symptoms according to Bell’s classification (Fig 8) | ||||
correlated with hostility | ||||
Rt. Insula (BA 13) | (33.7, -41.8, 18.7) | 0.003 | 6.87 | 146 |
correlated with positive symptoms | ||||
Rt. parahippocampal gyrus (BA19) | (39.6, -40.7, 2.0) | 0.000 | 9.19 | 486 |
Areas where BOLD activity significantly correlated positively with BOLD signal change in the bilateral Heschl’s Gyri. (Figs 10 and 11). | ||||
correlated Lt. Heschl gyrus | ||||
Lt. insula (BA 13) | (43.6, -15.2, 6.3) | 0.000 | 12.20 | 1107 |
Lt. postcentral gyrus (BA43) | (63.4, -10.6, 20.8) | 0.000 | 21.46 | 218 |
Lt. inferior parietal lobule (BA 40) | (-55.4, -25.5, 34.4) | 0.020 | 6.75 | 97 |
Rt insula | (—4.0 -40.0, 14.9) | 0032 | 5.57 | 88 |
correlated with Rt. Heschl gyrus | ||||
Rt. insula (BA 13) | (43.6, 3.5, -6.9) | 0.018 | 6.13 | 105 |
Lt. posterior cingulate(BA29) | (-2.0, -42.0, 15.0) | 0.008 | 7.96 | 123 |
Lt. middle frontal gyrus (BA 9) | (-29.7, 30.3, 22.4) | 0.005 | 5.60 | 134 |
BA: Brodmann area
FWE: family-wise error rate