Table 1.

Phase diagram of MO/DOTAP lipid films with and without siRNA. RH stands for relative air humidity. ${\mathrm{Q}}_{\text{II}}^{\mathrm{G}}$, H_II, L_α symbols represent a bicontinuous gyroid cubic, an inverted hexagonal, and a lamellar phase, respectively. Adapted from ^[16]. Copyright 2016 WILEY-VCH.

Molar Ratio (mol%/mol%)	Dry Film (25°C, 20~40% RH)		Wet Film (37°C, 95±5% RH)		Bulk Solution (37°C)
GMO/DOTAP	− siRNA	+ siRNA	− siRNA	+ siRNA	− siRNA	+ siRNA
85/15	Lα	Lα	${\mathrm{Q}}_{\text{II}}^{\mathrm{G}}$	${\mathrm{Q}}_{\text{II}}^{\mathrm{G}}$	${\mathrm{Q}}_{\text{II}}^{\mathrm{G}}$	${\mathrm{Q}}_{\text{II}}^{\mathrm{G}}$
75/25	Lα/HII	Lα/HII	${\mathrm{Q}}_{\text{II}}^{\mathrm{G}}$	${\mathrm{Q}}_{\text{II}}^{\mathrm{G}}$	${\mathrm{Q}}_{\text{II}}^{\mathrm{G}}$	${\mathrm{Q}}_{\text{II}}^{\mathrm{G}}$
70/30	HII	HII	${\mathrm{Q}}_{\text{II}}^{\mathrm{G}}$	${\mathrm{Q}}_{\text{II}}^{\mathrm{G}}$+HII	${\mathrm{Q}}_{\text{II}}^{\mathrm{G}}$	HII
60/40	HII	HII	${\mathrm{Q}}_{\text{II}}^{\mathrm{G}}$	${\mathrm{Q}}_{\text{II}}^{\mathrm{G}}$ +HII	${\mathrm{Q}}_{\text{II}}^{\mathrm{G}}$	HII+Lα
50/50	HII	HII	Lα	Lα	Lα	Lα
25/75	HII	HII	Lα	Lα	Lα	Lα