Fig 1. The effect of anesthetics on cross-talk of Fc receptor and Mac-1 for phagocytosis.

Targets opsonized with IgG and Mac-1 ligand will be captured by macrophages via their Fc receptors (FcRs) and Mac-1. Mac-1 consists of α- and β-subunits as shown in the scheme. Rap 1 is activated by FcRs after FcRs engage with IgG. Activated Rap1 can activate protein called RapL, which interacts with α subunit of Mac-1. Activated Mac-1 can activate Rap1 via protein Talin. As shown in the scheme, Rap1 will receive signal from both FcRs and Mac-1 to form phagocytic cup.