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. 2019 May 9;14(5):e0216628. doi: 10.1371/journal.pone.0216628

Fig 4.

Fig 4

A. Type I TGFβ receptor levels are significantly (p < 0.0001) lowered in the presence of MFS-like mutant type II TGFβ receptors as determined by confocal imaging. A GFP-tagged type I receptor SMA-6 was co-expressed in the intestine with an untagged wild-type or MFS-like mutant type II receptor. B. The type I receptor, SMA-6, degraded in the presence of the MFS-like type II receptor was restored by inhibition of the lysosome function by knockdown of cup-5 RNAi. C. Overexposure of the confocal images reveals that the presence of mutant type II receptors significantly (p < 0.005) altered the intracellular distribution of the type I receptors from the basolateral surfaces to the apical/sub-apical surfaces of the intestine.