Fig 6. Reliability of inter-layer multi-scale community allegiance of brain regions in SC and FC graphs.

(A) The percentage of brain regions from the SC (blue) and FC (red) graphs containing inter-layer edges with significant probability at the group-level across layers, which in our case track γ increments. The probability of identifying the SC inter-layer edges falls below chance for the second half of the γ range values. These results suggest that the estimated stability and the hierarchical structure of the higher γ layers are unreliable. Inter-layer coupling weights were (τ = 0.50). The probability of identifying the FC inter-layer edges was above the significance level for a small range of γ values. Since the vast majority of the group-level consensus inter-layer edges are not significant, the identified communities frequently switch across layers (as seen in (Fig 4C)). (B-C) The regions from the SC (panel (B)) and FC (panel (C)) graphs containing inter-layer edges with significant probability at the group-level are overlayed on the brain and color-coded to represent the ratio of the significant inter-layer edges (i.e., by dividing by the total number of inter-layer edges).