Table 2. IC50 concentrations and selectivity indices for WU-1 in GLUT5 and GLUT8 overexpressing cells.
Cell Line | 2-DG (μM) | Selectivity Index | Frc (μM) | Selectivity Index |
---|---|---|---|---|
PfHT1 | 5.8 ± 0.6 | 1.0 | 5.0 ± 0.7 | 1.0 |
GLUT5 | n.d. | n.d. | n.i. | n.i. |
GLUT8 | 25.0 ± 7.5 | 4.3 | 22.0 ± 1.2 | 4.4 |
IC50 determinations for 2-DG and [3H] D-fructose uptake by PfHT-, GLUT5- and GLUT8-over-expressing cells were determined as described in Materials and Methods. The selectivity indices for PfHT over the individual GLUT proteins was calculated using these numbers. n.d. = not determined; n.i = Not inhibited.