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. 2019 May 9;14(5):e0216457. doi: 10.1371/journal.pone.0216457

Table 2. IC50 concentrations and selectivity indices for WU-1 in GLUT5 and GLUT8 overexpressing cells.

Cell Line 2-DG (μM) Selectivity Index Frc (μM) Selectivity Index
PfHT1 5.8 ± 0.6 1.0 5.0 ± 0.7 1.0
GLUT5 n.d. n.d. n.i. n.i.
GLUT8 25.0 ± 7.5 4.3 22.0 ± 1.2 4.4

IC50 determinations for 2-DG and [3H] D-fructose uptake by PfHT-, GLUT5- and GLUT8-over-expressing cells were determined as described in Materials and Methods. The selectivity indices for PfHT over the individual GLUT proteins was calculated using these numbers. n.d. = not determined; n.i = Not inhibited.