Table 1. Percentage of secondary structures of 5G4 mAb and Herceptin by DichroWeb.
Secondary Structures (%) | 5G4 mAb | Herceptin | |||||
---|---|---|---|---|---|---|---|
Batch 1 | Batch 2 | Batch 3 | Mean ± SD | Batch 1 | Batch 2 | Mean ± SD | |
α-helices | 6.0 | 6.0 | 7.4 | 6.5 ± 0.8 | 6.2 | 6.0 | 6.1 ± 0.1 |
β-sheets | 56.1 | 56.0 | 53.7 | 55.2 ± 1.4 | 55.5 | 55.9 | 55.7 ± 0.3 |
Disordered structures | 37.9 | 37.4 | 39.0 | 38.1 ± 0.8 | 38.4 | 38.2 | 38.3 ± 0.1 |
Nrmsd | 0.172 | 0.163 | 0.181 | 0.158 | 0.182 |
Nrmsd, Normalized root-mean-square deviation; SD, Standard deviation.