Fig 2. The condensation of r* within [1, 2] and its dependance on the stage durations.

All kinetic rates are estimated from [15] in the transcription of Oct4 gene in mouse embryonic stem cells. (A) For almost all the ${\mathbb{S}}_1$ and ${\mathbb{S}}_2$ stage durations ranging from 10 to 1, 000 min, r* is within a narrow range [1, 2]. When 1/κ₁ ≫ 1/κ₂ (or 1/κ₁ ≪ 1/κ₂), r* varies slowly over a narrow region around 1 (or 2). When the two durations are close, r* changes rapidly over (1.1, 2). (B) When the ${\mathbb{S}}_1$ stage duration is far greater than the ${\mathbb{S}}_2$ stage duration, r* < 1 and is very close to 1. (C) When the ${\mathbb{S}}_2$ stage duration is far greater than the ${\mathbb{S}}_1$ stage duration, r* > 2 and is very close to 2.