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. Author manuscript; available in PMC: 2019 May 9.
Published in final edited form as: Cell Rep. 2019 Mar 26;26(13):3574–3585.e3. doi: 10.1016/j.celrep.2019.02.109

Figure 2. Measure of M. leprae mRNA:rRNA Ratio.

Figure 2.

(A) M. leprae derived from the footpad of nu/nu mice were isolated and cultured in vitro under starvation conditions for 0 h, 48 h, or 96 h before RNA extraction and RNA sequencing. Data are shown as mean transcriptional activity ± SEM per time point (n = 2). *p < 0.05 by Student’s t test.

(B) Ratio of the log2(x + 1)-transformed sum of all M. leprae mRNA genes divided by 23S RNA abundance per L-lep lesion.

(C) Plot of RNA abundance versus mRNA:rRNAM. leprae measures per L-lep patient.

(D) Scatterplots of M. leprae transcriptional activity versus indicated SaVanT signature score per L-lep patient. p value by Student’s t test (n = 9).

See also Table S2 and Figures S2, S3, and S4.