Table 2.

- RAD51D PolyPhen-2 analysis. RAD51D isoform 1 was entered in FASTA format along with the amino acid substitution and position information. Mutation scores were generated along with a prediction of whether the mutation would be benign, possibly or probably damaging. Mutations analyzed were selected on the basis of the mutation being ‘possibly damaging’ or ‘probably damaging’.

Mutation	Score	Prediction
R55C	0.936	Possibly Damaging
D70N	0.933	Possibly Damaging
E73K	0.9	Possibly Damaging
D90G	0.735	Possibly Damaging
G96C	0.999	Probably Damaging
G107V	1	Probably Damaging
C130E	0.999	Probably Damaging