Figure 2.
rBTNL2-Ig treatment delays the onset and reduces the incidence of autoimmune diabetes. Female NOD mice were injected i.p. with rBTNL2-Ig (25 or 50 µg) or control Ig (25 µg) twice weekly from 4 to 16 weeks of age. The mice were monitored for blood glucose levels each week. Mice with blood glucose of greater than 250 mg/dL on two consecutive readings were considered diabetic. The percentages of onset of diabetes are plotted at 12, 16, 20, 24, 28 and 32 weeks of age. The data are pooled from 3 independent experiments with 4–6 mice per group.