Skip to main content
. Author manuscript; available in PMC: 2020 May 8.
Published in final edited form as: Neuron. 2019 Mar 12;102(3):574–586.e5. doi: 10.1016/j.neuron.2019.02.015

Figure 5. Pharmacological or genetic inhibition of RAR reduces hyperactivity in the degenerated rd1 retina.

Figure 5.

(A) MEA recordings of spontaneous activity in the dark, in a naive rd1 retina (left), and in a BMS 493-injected rd1 retina (right), both in saline.

(B) Quantification of spontaneous activity in rd1 control retinas (‘Ctrl.’, non-injected eyes), in rd1 retinas injected with 0.5 μM BMS 493 3–7 days prior to the experiment, and in rd1 retinas from P90 mice, injected at P30 with AAV2-RARDN. Values represent the mean Firing Rate (Hz) ± SEM. *p<0.05, **p<0.01, one-way ANOVA. For full datasets, see Table S1.