Fig. 5.

DAPK inhibition regulates cell viability and increases cytotoxicity in human epileptic brain endothelial cells and astrocytes. a DAPK inhibition shows significant decrease (*p < 0.05) in cell viability (as percentage) in EPI-ECs and EPI-astro compared to respective untreated cells determined by MTT assay. The control cells (HBMEC and HA) showed negligible alteration. b Additional evaluation of cell stress showed cytotoxicity and corresponding increase in AK levels in EPI-ECs (*p < 0.05) and EPI-astro (*p < 0.05) compared to untreated cells subsequent to DAPK inhibition which is indicative of possible involvement of DAPK in cell survival during pathological condition