Table 2.

Comparison of the Hyperinsulinemic Normoglycemia vs. Standard Therapy groups on Secondary Outcomes

Outcomes	Hyperinsulinemic Normoglycemia (N = 709)		Standard Therapy (N = 730)
	N	Median (95% CI)	N	Median (95%CI)	HR (99.83%CI)*	P-value*
ICU stay (hrs)						0.046b
	649	25(24.9, 26.3)	671	27 (25.2, 27.3)	1.13 (0.95, 1.35)	0.025
Hospital stay (days)**						0.07 b
	686	8 [6, 12]	713	8 [6, 12]	1.05 (0.89, 1.25)	0.35
	N	Event (%)	N	Event (%)	RR (99.83%CI)*
Postoperative atrial fibrillation						0.51 b
	709	209 (29)	730	235 (32)	0.92 (0.75,1.13)	0.29
Any minor complicationa						0.21 b
	709	194(27)	730	227(31)	0.95 (0.87,1.04)	0.13
1-year mortality						0.13 b
	653	32 (5)	682	22 (3)	1.52 (0.74,3.11)	0.12

^*Confidence intervals and P values from Cox proportional hazards for ICU stay and Hospital stay, and Cochran-Mantel-Haenszel test for binary outcomes. Confidence intervals adjusted for group sequential design using confidence coefficient of 2.633 for combined sites in order to maintain overall study alpha of 0.05. Significant if P < 0.0085 /6 = 0.0017 using Bonferroni correction.

^**The observed longest hospital stay + 1 day was assigned to patients who died during hospitalization (N = 22).

^aMinor complications include any one of the following: a prolonged requirement for mechanical ventilation (>72 hours), low cardiac index (cardiac index <1.8 l/min/m² despite adequate fluid replacement and high dose inotropic support for >4 hours), acute kidney injury (increase in creatinine >100%), prolonged hospitalization (>30 days), and all-cause hospital readmission within 30 days).

^btreatment × site P-value.