Fig. 4.

Longer time window to integrate excitation in L5BL vs L2/3 pyramidal neurons. a Example of the compound EPSCs (red) and IPSCs (blue) evoked in a pair formed by a L2/3 and a L5BL pyramidal neurons sequentially recorded. Stimulus intensity: 200 µA. Each trace represents the average of ten consecutive responses normalized to peak amplitude. cEPSCs have been inverted to facilitate comparison with cIPSCs. b–d Latency of the cEPSC (b), cIPSC (c) and cIPSC–cEPSC latency (d) in a paired sample of L2/3 and L5BL pyramidal neurons (same as in Fig. 4). Notice that with intermediate (b–d, left panels) but not with near-maximal stimulus intensities (b–d, right panels), there is a significantly longer time window to integrate excitatory input before the arrival of inhibition in L5BL vs L2/3 pyramidal neurons