Table 2.
Comparison of analytical performances of different techniques based on phenylboronic acid used for glycoprotein detection
| Target analyte | Sensing principle | Sensor preparation method | Linear range | Limit of detection (LOD) | Ref |
|---|---|---|---|---|---|
| Dopamine | Electrochemical | Molecularly imprinted poly (acrylamidophenylboronic acid) film | 5 × 10−9 M–2 × 10−6 M | 20 × 10−9 M | [63] |
| Carcinoembryonic antigen (CEA) | Electrochemical | Self-assembling of a thiol-mixed monolayer comprised of 3-APBA with 11-mercaptoundecanoic acid and 11-mercapto-1-undecanol on gold | 1.25–20 × 10−15 M | 0.55 × 10−15 M | [48] |
| Dopamine | Impedimetric biosensor | Electropolymerization of 3-APBA on a preformed polyaniline layer | 1 × 10−10 M–1 × 10−5 M | 1 × 10−10 M | [57] |
| Ovalbumin | Electrochemical | Magnetic ferriferous oxide nanoparticles functionalized by phenylboronic acid | 2.2 × 10−8 M–44 × 10−8 M | 2.75 × 10−9 M | [67] |
| Prostate specific antigen (PSA) | Reusable amperometric immunosensor | Enzyme conjugated anti-PSA antibody reversible binding with a self-assembled phenylboronic acid monolayer on gold | 6–45 × 10−11 M and 45–60 × 10−11 M | N/D | [64] |
| Dopamine | Imprinted electrochemical sensor | Molecular imprinting based sensor using pyrrole-phenylboronic acid as the electropolymerized monomer | 5.0 × 10−8 M–1.0 × 10−5 | 3.3 × 10−8 M | [68] |
| Horse radish peroxidase (HRP) | Electrochemical | Self-assembly of 4-mercaptophenylboronic acid on dendritic gold nanoparticles | 2.5 × 10−9 M–25 × 10−6 M | 0.5 × 10−9 M | [66] |
| Adrenocorticotropic hormone (ACTH) | Electrochemical immunosensor | Use of APBA for the oriented immobilization of Anti-ACTH antibodies onto screen-printed carbon modified electrode surface | 2.2 × 10−16 M–1.1 × 10−13 M | 4.0 × 10−17 M | [65] |
| Dopamine | Fluorescence titration | Fluorescence sensory membrane based on the design of an acrylic monomer with a phenylboronic acid residue conjugated with an aromatic imino group and a phenyl ring | 4.76 × 10−5 M–1.01 × 10−1 M | 3–4 × 10−4 M | [15] |
| Pathogenic influenza A virus | Quartz crystal microbalance (QCM) and surface plasmon resonance (SPR) | Use of 4-aminophenyl boronic acid (4-APBA) as a ligand for binding of sialic acid (SA) via boronic acid–sugar interaction which then interacts with hemagglutinin protein on Influenza A virus | 0.01 × 10−3 M–0.16 × 10−3 M | 4.7 × 10−8 M for QCM and 1.28 × 10−7 M for SPR | [62] |
| Human immunoglobulin G (IgG) | Capacitive biosensor | Preparation of APBA moieties onto tyramine-electropolymerized gold electrodes | 1.0 × 10−13 M–1.0 × 10−7 M | 16 × 10−15 M | In this study |