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. 2019 May 3;10:410. doi: 10.3389/fgene.2019.00410

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Copyright © 2019 Gao, Xu, Chen, Xue, Pan, Zhou, Ma and Ma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RT-qPCR validation of DEGs in smn-1(ok355) single mutants. Relative expression of mitochondrial genes (A), V-ATPase subunit genes (B), ugt genes (C), and cyp genes (D) in smn-1(ok355) mutants. The corresponding mammalian homologs are indicated in parentheses. (E) Gene structures of replication-dependent and -independent histone genes and positions of PCR primers. HDE (red): presumably C. elegans-specific histone downstream element (Keall et al., 2007). Poly(A) signals are indicated as blue boxes. (F) Validation of histone gene expression. For replication-dependent histone genes, total transcripts and poly(A)+ transcripts were reversely transcribed using random primers and oligo(dT) primers, respectively. Each dataset is the average of three biological replicates. Statistics: two-tailed unpaired Student’s t-test. ^∗p < 0.05; ^∗∗p < 0.01; ^∗∗∗p < 0.001. Error bars: standard errors.