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. 2019 May 3;10:410. doi: 10.3389/fgene.2019.00410

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Copyright © 2019 Gao, Xu, Chen, Xue, Pan, Zhou, Ma and Ma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RT-PCR examination of alternative splicing in smn-1(ok355) mutants. smn-1(ok355) increased the intron retention of the abt-5 gene (A) and the recognition of an alternative 3′ splice site of the flp-1 gene (B). (C) smn-1(ok355) and uaf-1(n4588) together can increase the intron retention of the gcy-11 gene. (D) smn-1(ok355) can strongly suppress the recognition of a cryptic 5′ splice site in uaf-1(n4588) mutants. Representative gel pictures, gene structures and splicing quantifications are shown from left to right, with genotypes indicated at the bottom. Red arrows: positions of PCR primers. Each dataset is the average of three biological replicates. Statistics: Bonferroni multiple comparison with one-way ANOVA. ^∗p < 0.05; ^∗∗p < 0.01; ^∗∗∗p < 0.001. Error bars: standard errors.