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. 2019 May 3;10:982. doi: 10.3389/fimmu.2019.00982

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Copyright © 2019 Barcenilla, Åkerman, Pihl, Ludvigsson and Casas.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Subset identification within the major immune populations in peripheral mononuclear cells from high-risk (n = 9) and control individuals (n = 9). (A) Phenotypically distinct subsets were identified with t-SNE combined with Phenograph analysis of each lineage population (colored areas) (B) Heatmap showing median expression of the markers expressed by the cell subsets identified in (A). Subsets of CD4+ (11,18,19,22,25), CD8+ (15, 20, and 22), CD4-CD8- (11,16), B (9,10,13,15,16) NK (6,9,13,15,20), mDC (2,7,8) and pDC (5) were excluded from the heatmap. Cytokine (IL-2, IFNγ, IL-17A, IL-10, and IL-4) expression is shown as subtraction of the expression on un-stimulated PBMC from samples stimulated with PMA+ ionomycin. Values were transformed using arcsinh function in a cofactor of 5.