Table 2.
Brain MRI findings in the RMS and SPMS patients at study baseline and at 2 years.
| RRMS | SPMS | p-value | ||||
|---|---|---|---|---|---|---|
| Variable | Baseline | Follow-up | Baseline | Follow-up | Baseline | Follow-up |
| N | 24 | 23 | 36 | 35 | ||
| Gd+ lesions (N, %) | 4/24 (17) | 1/23 (4) | 2/36 (6) | 4/35 (11) | 0.248 | 0.677 |
| Total BP vol. (ml, SD) | 1509.5 (109.26) | 1482.3 (110.87) | 1397.9 (107.11) | 1404.7 (107.49) | 0.001 | 0.012 |
| Total WM vol. (ml, SD) | 688.6 (51.40) | 678.0 (45.09) | 648.1 (49.05) | 652.9 (53.10) | 0.011 | 0.084 |
| Total GM vol. (ml, SD) | 820.7 (67.03) | 804.1 (74.16) | 749.9 (66.24) | 751.7 (67.66) | <0.001 | 0.007 |
| WM lesion vol. (ml, SD) | 11.0 (8.35) | 10.2 (8.43) | 20.2 (12.26) | 20.4 (13.29) | <0.001 | <0.001 |
| Putamen vol. (ml, SD) | 4.4 (0.58) | 4.4 (0.61) | 4.0 (0.63) | 4.0 (0.67) | 0.020 | 0.065 |
| Hippocampus vol. (ml, SD) | 3.9 (0.48) | 3.9 (0.55) | 3.5 (0.44) | 3.4 (0.48) | 0.008 | 0.006 |
| Thalamus vol. (ml, SD) | 7.2 (0.80) | 7.3 (0.82) | 6.2 (0.95) | 6.2 (0.97) | <0.001 | <0.001 |
| Nucleus caudatus vol. (ml, SD) | 2.9 (0.41) | 2.8 (0.45) | 2.5 (0.40) | 2.5 (0.43) | <0.001 | 0.014 |
| Globus pallidus vol. (ml, SD) | 1.3 (0.15) | 1.2 (0.16) | 1.1 (0.14) | 1.1 (0.14) | 0.003 | 0.020 |
| Cerebellum WM vol. (ml, SD) | 15.7 (2.36) | 15.8 (2.25) | 11.9 (2.97) | 11.6 (2.62) | <0.001 | <0.001 |
| Cerebellum GM vol. (ml, SD) | 55.1 (5.18) | 57.1 (5.92) | 54.7 (7.21) | 54.1 (7.34) | 0.769 | 0.127 |
The bold values indicate statistically significant p-values.