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. 2019 May 3;9:341. doi: 10.3389/fonc.2019.00341

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Copyright © 2019 Ghosh, McCormick and Weinberg.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) HBD-1,-2, and−3 either increased (red arrow) or decreased (green arrow) in cancers from different anatomical locations within human body (as indicated). (B) HBD-1,-2, and−3 either promote (red arrow) or inhibit (green arrow) migration/proliferation of cancers cells derived from different anatomical locations (as indicated). (C) Effector molecules/pathways by which each of the three defensins (hBD-1,−2, and−3) are dysregulated in cancers.