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. 2019 May 9;9:7175. doi: 10.1038/s41598-019-43133-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic representation of the two proposed scenarios that could explain the origin of the TGM1: c.1187A > G mutation. (A) This model suggests the Galician (Spanish) origin of the c.1187A > G mutation found in Ecuadorian families. The geographic location of the Ecuadorian families (Manabí province) is indicated as circles. Largest Ecuadorian cities were also marked as reference points. (B) This model represents the dual origin, Ecuadorian and European, of the c.1187A > G mutation as a result of two independent mutational events.