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. 2019 May 9;9:7122. doi: 10.1038/s41598-019-43575-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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APOBEC3B promotes DNA double-strand breaks in myeloma cells. (a) Fluorescence immunostaining of γ-H2AX in RPMI8226 and AMO1 cells transduced with either control or A3B shRNA lentivirus. The images were obtained by confocal fluorescence microscopy (magnification, 630x). (b) Statistical analysis of the number of γ-H2AX foci per cell in RPMI8226 and AMO1 cells based on the images in (a). Approximately 200 cells were evaluated for each sample. All P values were calculated using Student’s t test. (c) Immunoblot analysis of γ-H2AX in RPMI8226 cells transduced with either control or A3B shRNA lentivirus. (d) Bar graph of the γ-H2AX band intensities from (c) normalized by the α-tubulin band intensity.