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. 2019 May 9;9:7160. doi: 10.1038/s41598-019-43682-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of miR-21 and miR-10 on wound closure. (A) Mouse skin wounds (n = 6) were treated with miR-21 mimic or negative control mimic at the time of injury, and wound closure was measured for 10 days. Statistical significant changes in wound closure were observed between wounds treated with miR-21 mimic and wounds treated with negative control mimic (two-way ANOVA test p < 0.0001). *Indicates statistical significant difference at specific time point (multiple t-test p < 0.05). Statistical analyses were presented in Supplementary Table S8. (B) Representative photomicrographs of microRNA mimic treated wounds taken at the time points indicated. (C) Mouse skin wounds (n = 6) were treated with LNA inhibitor for miR-10b or negative control LNA at the time of injury, and wound closure was measured for 10 days. Statistical significant changes in wound closure were observed between wounds treated with miR-10b LNA inhibitor and wounds treated with negative control LNA (two-way ANOVA test p = 0.0001). *Indicates statistical significant difference at specific time point (multiple t-test p < 0.05). Statistical analyses were presented in Supplementary Table S8. (D) Representative photomicrographs of LNA treated wounds taken at the time points indicated. Scale bar = 2 mm.