Table 4.
Comparison of genotypic distributions between the inactive group and patients with active HBV, cirrhosis and HCC patients.
| SNPs | Genotype/Allele distribution | Inactive (n = 563) | % | Active, cirrhosis and HCC (n = 311) | % | OR (95% C.I.) | χ² | p-value |
|---|---|---|---|---|---|---|---|---|
| rs2723176 | CC | 518 | 92.01% | 276 | 88.75% | Ref | ||
| AC | 42 | 7.46% | 33 | 10.61% | 1.475 (0.914–2.380) | 2.550 | 0.110 | |
| AA | 3 | 0.53% | 2 | 0.64% | 1.251 (0.208–7.533) | 0.060 | 0.806 | |
| C | 1078 | 95.74% | 585 | 94.05% | 1.420 (0.914–2.206) | 2.460 | 0.117 | |
| A | 48 | 4.26% | 37 | 5.95% | ||||
| AA + AC vs CC | 1.460 (0.917–2.325) | 2.560 | 0.109 | |||||
| AA vs AC + CC | 0.828 (0.138–4.980) | 0.040 | 0.836 | |||||
| rs2723175 | GG | 374 | 66.43% | 217 | 69.77% | Ref | ||
| AG | 156 | 27.71% | 82 | 26.37% | 0.906 (0.661–1.242) | 0.380 | 0.539 | |
| AA | 33 | 5.86% | 12 | 3.86% | 0.627 (0.317–1.239) | 1.830 | 0.176 | |
| G | 904 | 80.28% | 516 | 82.96% | 0.837 (0.648–1.080) | 1.880 | 0.170 | |
| A | 222 | 19.72% | 106 | 17.04% | ||||
| AA + AG vs GG | 0.857 (0.636–1.155) | 1.020 | 0.312 | |||||
| AA vs AG + GG | 1.551 (0.789–3.049) | 1.650 | 0.199 | |||||
| rs2723186 | GG | 509 | 90.41% | 273 | 87.78% | Ref | ||
| AG | 30 | 5.33% | 24 | 7.72% | 1.492 (0.855–2.602) | 2.00 | 0.157 | |
| AA | 24 | 4.26% | 14 | 4.50% | 1.088 (0.554–2.137) | 0.060 | 0.807 | |
| G | 1048 | 93.07% | 570 | 91.64% | 1.226 (0.851–1.766) | 1.200 | 0.274 | |
| A | 78 | 6.93% | 52 | 8.36% | ||||
| AA + AG vs GG | 1.312 (0.845–2.038) | 1.470 | 0.226 | |||||
| AA vs AG + GG | 0.945 (0.481–1.854) | 0.030 | 0.868 | |||||
| rs2723168 | AA | 23 | 4.09% | 12 | 3.86% | Ref | ||
| AG | 537 | 95.38% | 297 | 95.50% | 1.060 (0.520–2.161) | 0.030 | 0.872 | |
| GG | 3 | 0.53% | 2 | 0.64% | 1.278 (0.187–8.720) | 0.060 | 0.802 | |
| A | 583 | 51.78% | 321 | 51.61% | 1.007 (0.828–1.225) | 0.00 | 0.946 | |
| G | 543 | 48.22% | 301 | 48.39% | ||||
| GG + AG vs AA | 1.061 (0.521–2.163) | 0.030 | 0.869 | |||||
| GG vs AG + AA | 0.828 (0.138–4.980) | 0.040 | 0.836 | |||||
| rs4364030 | CC | 268 | 47.60% | 160 | 51.45% | Ref | ||
| CG | 241 | 42.81% | 116 | 37.30% | 0.806 (0.600–1.084) | 2.040 | 0.153 | |
| GG | 54 | 9.59% | 35 | 11.25% | 1.086 (0.680–1.734) | 0.120 | 0.731 | |
| C | 777 | 69.01% | 436 | 70.10% | 0.950 (0.767–1.175) | 0.220 | 0.636 | |
| G | 349 | 30.99% | 186 | 29.90% | ||||
| GG + CG vs CC | 0.857 (0.650–1.131) | 1.190 | 0.276 | |||||
| GG vs CG + CC | 0.837 (0.534–1.312) | 0.610 | 0.436 | |||||
| rs3811047 | GG | 160 | 28.42% | 123 | 39.55% | Ref | ||
| AG | 267 | 47.42% | 151 | 48.55% | 0.736 (0.540–1.001) | 3.820 | 0.051 | |
| AA | 136 | 24.16% | 101 | 32.48% | 0.966 (0.682–1.369) | 0.040 | 0.846 | |
| G | 587 | 52.13% | 397 | 63.83% | 0.968 (0.805–1.165) | 0.120 | 0.733 | |
| A | 539 | 47.87% | 353 | 56.75% | ||||
| AA + AG vs GG | 0.813 (0.613–1.079) | 2.050 | 0.152 | |||||
| AA vs AG + GG | 0.864 (0.641–1.165) | 0.920 | 0.338 | |||||
| rs28947200 | CC | 499 | 88.63% | 272 | 87.46% | Ref | ||
| CT | 49 | 8.70% | 31 | 9.97% | 1.161 (0.723–1.863) | 0.380 | 0.537 | |
| TT | 15 | 2.66% | 8 | 2.57% | 0.978 (0.410–2.337) | 0.00 | 0.961 | |
| C | 1047 | 92.98% | 575 | 92.44% | 1.083 (0.744–1.576) | 0.170 | 0.676 | |
| T | 79 | 7.02% | 47 | 7.56% | ||||
| TT + CT vs CC | 1.118 (0.731–1.709) | 0.260 | 0.606 | |||||
| TT vs CT + CC | 1.037 (0.435–2.473) | 0.010 | 0.935 | |||||
| rs4392270 | GG | 522 | 92.72% | 274 | 88.10% | Ref | ||
| AG | 29 | 5.15% | 25 | 8.04% | 1.642 (0.943–2.860) | 3.130 | 0.077 | |
| AA | 12 | 2.13% | 12 | 3.86% | 1.905 (0.845–4.297) | 2.490 | 0.115 | |
| G | 1073 | 95.29% | 573 | 92.12% | 1.731 (1.159–2.587) | 7.330 | 0.007 | |
| A | 53 | 4.71% | 49 | 7.88% | ||||
| AA + AG vs GG | 1.719 (1.077–2.745) | 5.250 | 0.022 | |||||
| AA vs AG + GG | 0.543 (0.241–1.223) | 2.240 | 0.135 | |||||
| rs4849133 | TT | 463 | 82.24% | 243 | 78.14% | Ref | ||
| CT | 65 | 11.55% | 54 | 17.36% | 1.583 (1.069–2.345) | 5.310 | 0.021 | |
| CC | 35 | 6.22% | 14 | 4.50% | 0.762 (0.402–1.444) | 0.70 | 0.404 | |
| T | 991 | 88.01% | 540 | 86.82% | 1.115 (0.831–1.495) | 0.530 | 0.468 | |
| C | 135 | 11.99% | 82 | 13.18% | ||||
| CC + CT vs TT | 1.296 (0.918–1.829) | 2.170 | 0.141 | |||||
| CC vs CT + TT | 1.406 (0.745–2.656) | 1.110 | 0.291 | |||||
| rs2708973 | GG | 512 | 90.94% | 275 | 88.42% | Ref | ||
| AG | 39 | 6.93% | 26 | 8.36% | 1.241 (0.740–2.082) | 0.670 | 0.412 | |
| AA | 12 | 2.13% | 10 | 3.22% | 1.552 (0.662–3.637) | 1.040 | 0.309 | |
| G | 1063 | 94.40% | 576 | 92.60% | 1.347 (0.909–1.997) | 2.220 | 0.136 | |
| A | 63 | 5.60% | 46 | 7.40% | ||||
| AA + AG vs GG | 1.314 (0.837–2.063) | 1.520 | 0.234 | |||||
| AA vs AG + GG | 0.656 (0.280–1.535) | 0.960 | 0.327 |
Bold indicates significance.