. 2019 May 7;29(5):1028–1044. doi: 10.1016/j.cmet.2019.03.009

Table 1.

Epigenetic Association Studies of Obesity

Reference	Sample Size Discovery (Replication)	Phenotype	Tissue	Identified Number of CpG Sites	Additional Information
Xu et al., 2013	96	BMI ≥30 versus BMI <25	peripheral blood leukocytes	23,305 ^FDR	age: 14–21 years
Dick et al., 2014	459	BMI	whole blood	5 ^FDR	–
	339	BMI		3^Bonf
	1,789	BMI		3^Bonf
Aslibekyan et al., 2015	991	BMI	CD4+ T cells	8 ^Bonf	–
	991	waist circumference	CD4+ T cells	5 ^Bonf
	1,935	BMI	whole blood	4^Bonf
	2,105	BMI	whole blood	2^Bonf
	2,105	waist circumference	whole blood	3^Bonf
Demerath et al., 2015	2,097	BMI	peripheral blood leukocytes	76 ^Bonf	–
	2,097	waist circumference	peripheral blood leukocytes	164 ^Bonf
	2,377+991	BMI	whole blood/CD4+ T cells	37^Bonf
	991	waist circumference	CD4+ T cells	8^Bonf
Sayols-Baixeras et al., 2017	641/2,515	BMI	whole blood/whole blood	94 ^Bonf	results are based on a meta-analysis of discovery and replication cohorts
Sayols-Baixeras et al., 2017	641/2,515	waist circumference	whole blood/whole blood	49 ^Bonf
Wahl et al., 2017	5,387	BMI	whole blood	278 ^Bonf	^∗meta-analysis
Wahl et al., 2017	4,874	BMI	whole blood	187^{p < 0.05/*Bonf}	^∗meta-analysis
Mendelson et al., 2017	3,743	BMI	whole blood	135 ^Bonf	–
Mendelson et al., 2017	4,055	BMI	whole blood/CD4+ T cells	83^Bonf	–
Dhana et al., 2018	1,450	BMI	whole blood	14 ^Bonf	–
	1,450	waist circumference	whole blood	26 ^Bonf
	2,097	BMI	whole blood	12
	2,097	waist circumference	whole blood	13
Wang et al., 2018	700	BMI/obese versus lean	peripheral blood leukocytes	76 ^Bonf	age: 14–36 years
	2,097	BMI	peripheral blood leukocytes	54	–
	188	obese versus lean	neutrophils	37	–
Xu et al., 2018	510	BMI	whole blood	20 ^FDR	–
Rönn et al., 2015	96	BMI (males)	subcutaneous adipose tissue	33,058 ^FDR	–
Rönn et al., 2015	94	BMI (females)	subcutaneous adipose tissue	39,533 ^FDR	–
Benton et al., 2015	15	before versus after gastric by-pass (women)	omental adipose tissue	15 ^Bonf	–
Benton et al., 2015	15	before versus after gastric by-pass (women)	subcutaneous adipose tissue	3,601 ^Bonf	–
Dahlman et al., 2015	30	post-obese versus never obese (women)	isolated fat cells	8,504 ^FDR_1%	–
Fradin et al., 2017	37	obesity (BMI Z score > 2.5 versus lean controls)	whole blood	31 ^FDR	age: 3–13 years
Rzehak et al., 2017	374	BMI	whole blood	212 ^FDR	age: 5.5 years
Huang et al., 2015	149	BMI	whole blood	129 ^{(p<0.05; Δ>10%)}	age: 9–14 years

All studies are based on the Illumina 450k array. Results from replication(s) within the studies (where applicable) are marked in italic.

FDR, false discovery rate < 0.05; Bonf, Bonferroni correction for multiple testing; FDR_1%, FDR < 0.01.