Fig. 5.

Suggested protein–protein binding model for WntD/Toll. a The protein–protein binding between Drosophila Toll (a TLR4 homologue) and WntD (Wnt5a homologue) was modelled using Rosetta macromolecular modelling package⁴⁹. Energy landscapes from the docking perturbation simulations. In this plot the energy of models is plotted against root mean square deviation (rmsd) against the lowest energy model (interface rmsd). b A proposed protein–protein docking model of how WntD may interact with Toll