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The colorectal continuum theory that highlights the interaction between the gut microbiome and immune cells in the colorectal microenvironment. Certain characteristics of colorectal cancer [e.g. abundant intratumour Fusobacterium nucleatum (F. nucleatum)] represent a gradual transition along the colorectal axis without a clear cut-off at the splenic flexure [140,143]. CIMP, CpG island methylator phenotype; MSI, microsatellite instability.
