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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: J Pathol. 2019 Feb 20;247(5):615–628. doi: 10.1002/path.5236

Figure 6.

Figure 6.

The association between Fusobacterium nucleatum (F. nucleatum) and immune response to colorectal carcinoma depends on tumour microsatellite instability (MSI) status. A. The seemingly paradoxical relationship of F. nucleatum, tumour MSI status, and T lymphocyte infiltrates. B. The relationship of F. nucleatum with lymphocytic reaction according to tumour MSI status. F. nucleatum may exert immunosuppressive effects in MSI-high colorectal cancer, whereas F. nucleatum is associated with high-level lymphocytic reaction in non-MSI-high cancer in which immune reaction is generally inactive and the proinflammatory properties of F. nucleatum are thought to be dominant. MSI, microsatellite instability.