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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Chembiochem. 2018 Dec 27;20(3):394–407. doi: 10.1002/cbic.201800593

Scheme 4. Synthesis of 1s.

Scheme 4.

a). PCl5, ether, −15C - 0C, 3h. b). TMS-2-pyrrolidinone, ether, 0°C-r.t. 1.25h. c). TFA, thioanisole, TMSBr, r.t. 1.5h. d). benzohiazole-6-carboxylic acid, HBTU, HOAt, DIEA, DMF, CH2Cl2, r.t. overnight.