Table 1. Accuracy of swallowable devices for diagnosing Barrett’s esophagus.
Study | Device | Biomarker(s) | Sensitivity | Specificity | AUC |
---|---|---|---|---|---|
Wang, 2019 (16) | EsophaCap | p16 + NELL1 + AKAP12 + TAC1 + age | 94.4% (train), 78.6% (test) | 62.2% (train), 92.8% (test) | 0.883 (train), 0.929 (test) |
Iyer, 2018 (11) | EsophaCap | VAV3 + ZNF682 | 100% | 100% | 1.000 |
Moinova, 2018 (12) | JASSS balloon | CCNA1 + VIM | 90.3% | 91.7% | – |
Chettouh, 2018 (13) | Cytosponge | TFPI2, TWIST1, ZNF345, ZNF569 | 78.5% (TFPI2) | 96.9% (TFPI2) | 0.877 (TFPI2) |
Ross-Innes, 2015 (14) | Cytosponge | TFF3 | 79.9% (overall), 87.2% (≥3 cm BE) | 92.4% | – |
Kadri, 2010 (15) | Cytosponge | TFF3 | 73.3% (≥1 cm BE), 90.0% (≥2 cm BE) | 93.8% (≥1cm BE), 93.5% (≥2cm BE) | – |
‘Train’ and ‘test’ refer to training and testing sets, respectively.