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PTMs can regulate formation and material properties of condensates. A, PTMs have the potential to promote the assembly or disassembly of liquid-like condensates as well as the transition to gel- or solid-like condensates by enhancing or disrupting weak multivalent interactions between phase-separating RBPs. B, in a heterogeneous solution of macromolecules PTMs can regulate the recruitment or exclusion of specific protein or RNA molecules from or to MLOs.
