Table 1.
Current clinical trials in pemphigus.
NCT number | Disease | Interventions | Target | Allocation | Masking | Phase | Status |
---|---|---|---|---|---|---|---|
NCT01930175 | PV | VAY736 | BAFF-R | Randomized | Double blind | 2 | Active, not recruiting |
NCT01920477 | PV | Ofatumumab | CD20 | Randomized | Double blind | 3 | Completed |
NCT03334058 | PV | ARGX-113 | FcRn | Single group | None | 2 | Recruiting |
NCT02704429 | PV or PF | PRN1008 | BTK | Single group | None | 2 | Recruiting |
NCT03762265 | PV or PF | PRN1008 | BTK | Randomized | Quadruple blind | 3 | Recruiting |
NCT02383589 | PV | Rituximab MMF | CD20 IMPDH | Randomized | Double blind | 3 | Active, not recruiting |
NCT03239470 | PV or PF | Poly Tregs | Immune tolerance | Non- randomized | None | 1 | Recruiting |
NCT02828163 | PV | PRP | Wound healing | Randomized | Double blind | 3 | Recruiting |
NCT00784589 | PV or PF | Rituximab | CD20 | Randomized | None | 3 | Completed |
NCT03075904 | PV or PF | SYNT001 | FcRn | Non-randomized | None | 1/2 | Completed |
PV, pemphigus vulgaris; PF, pemphigus foliaceus; BAFF-R, B cell activating factor of the tumor necrosis factor family receptor; FcRn, neonatal Fc receptor; BTK, Bruton's tyrosine kinase; MMF, mycophenolate mofetil; IMPDH, inosine 5′-monophosphate dehydrogenase; Tregs, regulatory T cells; PRP, Platelet rich plasma.