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. 2019 May 3;10:978. doi: 10.3389/fimmu.2019.00978

Table 1.

Current clinical trials in pemphigus.

NCT number Disease Interventions Target Allocation Masking Phase Status
NCT01930175 PV VAY736 BAFF-R Randomized Double blind 2 Active, not recruiting
NCT01920477 PV Ofatumumab CD20 Randomized Double blind 3 Completed
NCT03334058 PV ARGX-113 FcRn Single group None 2 Recruiting
NCT02704429 PV or PF PRN1008 BTK Single group None 2 Recruiting
NCT03762265 PV or PF PRN1008 BTK Randomized Quadruple blind 3 Recruiting
NCT02383589 PV Rituximab MMF CD20 IMPDH Randomized Double blind 3 Active, not recruiting
NCT03239470 PV or PF Poly Tregs Immune tolerance Non- randomized None 1 Recruiting
NCT02828163 PV PRP Wound healing Randomized Double blind 3 Recruiting
NCT00784589 PV or PF Rituximab CD20 Randomized None 3 Completed
NCT03075904 PV or PF SYNT001 FcRn Non-randomized None 1/2 Completed

PV, pemphigus vulgaris; PF, pemphigus foliaceus; BAFF-R, B cell activating factor of the tumor necrosis factor family receptor; FcRn, neonatal Fc receptor; BTK, Bruton's tyrosine kinase; MMF, mycophenolate mofetil; IMPDH, inosine 5′-monophosphate dehydrogenase; Tregs, regulatory T cells; PRP, Platelet rich plasma.