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. 2019 Feb 25;133(15):1630–1643. doi: 10.1182/blood-2019-01-894980

Grading of recommendations

Grade Recommendation
A (Evidence-level quality Ia, Ib) Requires at least 1 randomized controlled trial as part of the body of literature of overall good, and consistency addressing the specific recommendation
B (Evidence levels IIa, IIb, III) Requires availability of well-conducted clinical studies but no randomized clinical trials on the topic of recommendation
C (Evidence level IV) Requires evidence from expert committee reports or opinions and/or clinical experience of respected authorities; indicates absence of directly applicable studies of good quality