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. 2019 Jan 2;133(11):1205–1216. doi: 10.1182/blood-2018-09-873083

Figure 2.

Figure 2.

Different biological profiles and clinical outcome among patients with CK (≥3 aberrations [abs]) depending on the number of chromosomal abnormalities. (A) Frequency of U-CLL (unmutated IGHV genes), TP53abs (deletion of chromosome 17p and/or TP53 mutations), del(11q) (deletion of chromosome 11q), and normal-FISH/idel(13q) (normal FISH or isolated deletion of chromosome 13q according to Döhner hierarchical model). Patients with CK and ≥5 aberrations (high-CK) are enriched for U-CLL and TP53abs compared with CK patients with 3 aberrations (low-CK) and those with 4 aberrations (intermediate-CK). Patients with normal-FISH(idel(13q) are detected within all CK groups. (B-D) Kaplan-Meier curves for OS. (B) All patients with CK in the entire cohort. Low-CK, intermediate-CK, and high-CK cases are represented with the blue, red, and green lines, respectively. (C) Patients without TP53abs. High-CK patients exhibit the shortest OS (purple line), whereas there is no difference between low-CK (red line), intermediate-CK (green line), and the remaining non-CK CLL (blue line). (D) Patients with TP53abs. The number of aberrations aggravates the clinical outcome, with high-CK (purple line) exhibiting the shortest OS.