Table 1.
Main clinicobiological features of the patients included in the study
| Feature | Entire cohort (n = 5290) | Non-CK (0-2 abs; n = 4496) | CK ≥3 abs (n = 794) | Low-CK/intermediate-CK (3-4 abs; n = 523) | High-CK (≥5 abs; n = 271) | P, non-CK vs CK | P, low-CK/intermediate-CK vs high-CK |
|---|---|---|---|---|---|---|---|
| Male | 3302/5290, 62% | 2790/4496, 62% | 522/794, 66% | 351/523, 67% | 171/271, 63% | .047 | .56 |
| Median age (diagnosis) | 64.6 y | 64.3 y | 64.7 y | 64.2 y | 66.1 y | .58 | .02 |
| MBL | 383/4454, 9% | 353/3813, 9% | 30/641, 5% | 27/412, 7% | 3/229, 1% | .0001 | .004 |
| Binet A | 3030/4454, 68% | 2643/3813, 69% | 387/641, 60% | 263/412, 64% | 124/229, 54% | <.0001 | .017 |
| Binet B/C | 1041/4454, 23% | 817/3813, 22% | 224/641, 35% | 122/412, 29% | 102/229, 45% | <.0001 | .0002 |
| U-CLL | 1514/3453, 44% | 1187/2939, 40% | 327/514, 64% | 201/351, 57% | 126/163, 77% | <.0001 | <.0001 |
| TP53abs | 657/4968, 13% | 337/4204, 8% | 320/764, 42% | 151/501, 30% | 169/263, 64% | <.0001 | <.0001 |
| del(11q) | 487/4500, 11% | 353/3714, 9% | 165/622, 26% | 119/413, 29% | 46/209, 22% | <.0001 | .07 |
| Trisomy 12 | 685/4500, 15% | 557/3714, 15% | 150/622, 24% | 117/413, 28% | 33/209, 16% | <.0001 | .0005 |
| idel(13q) | 1734/4500, 38% | 1621/3714, 44% | 113/622, 18% | 86/413, 21% | 27/209, 13% | <.0001 | <.0001 |
The statistically significant level was defined as .008 following the Bonferroni correction for multiple testing. abs, aberrations; CK, ≥3 abs; low-CK, 3 abs; intermediate-CK, 4 abs; high-CK, ≥5 abs; MBL, monoclonal B-cell lymphocytosis; TP53abs, deletion of chromosoe 17p and/or TP53 mutation; del(11q), deletion of chromosome 11q; idel(13q), isolated deletion of chromosome 13q.