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. 2019 May 3;10:955. doi: 10.3389/fimmu.2019.00955

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Copyright © 2019 Pobezinskaya, Wells, Angelou, Fagerberg, Aral, Iverson, Kimura and Pobezinsky.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Let-7 is essential in protecting T cells from apoptosis. Intracellular staining for active Caspase-3 (left) and frequency of acCasp3⁺ population (right) in CD4 and CD8 lymph node T cells from (A) wild type (n = 4) and Lin28Tg (n = 4) mice, (B) wild type (n = 6) and CD4Cre⁺Dicer^fl/fl (n = 6) mice, (C) Lin28Tg (n = 3) and Lin28TgLet7Tg (n = 3) mice, and (D) wild type (n = 4) and Let7Tg (n = 4) mice, cultured for 18 h in media. Data are representative of at least three independent staining experiments and are displayed as mean ± SEM of each population from all mice; n.s., not significant (p > 0.05), *p < 0.05, **p < 0.01, ***p < 0.001.