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. 2019 May 3;10:955. doi: 10.3389/fimmu.2019.00955

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Copyright © 2019 Pobezinskaya, Wells, Angelou, Fagerberg, Aral, Iverson, Kimura and Pobezinsky.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bcl2 expression is reduced in let-7 deficient T cells. (A) Quantitative RT-PCR analysis of Bcl2 expression, presented relative to expression of the ribosomal protein Rpl13a (left) and MFI of Bcl2 normalized to wild type (right) in CD8 T cells from lymph nodes of P14+Rag2KO wild type and P14+Lin28TgRag2KO mice. Data are displayed as mean ± SEM of technical triplicates (B) Intracellular staining for Bcl2 and active Caspase-3 in CD4 and CD8 lymph node T cells from wild type, Lin28Tg and Let7Tg mice, cultured for 18 h in media. Data are representative of three independent experiments (A) and two (A) and three (B) independent staining experiments; n.s., not significant (p > 0.05), ***p < 0.001.