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. 2019 May 3;10:1002. doi: 10.3389/fimmu.2019.01002

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Copyright © 2019 Pedragosa, Riera, Casella, Esteve-Codina, Steuerman, Seth, Bocharov, Heath, Gat-Viks, Argilaguet and Meyerhans.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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XCL1-producing CD8⁺ T cells express markers characteristic of early effector CD8⁺ T cells. (A) Box-plot representation of Xcl1, Tnfsf8, Tlr7, Ccr9, and Cd83 expression. Mean-normalized expression values (Log2) of selected genes in Ova-specific OT1 CD8⁺ T cells were obtained using “My GeneSet” tool from ImmGen (http://www.immgen.org/). (B) Mean fluorescence intensity (MFI) of Tnfsf8, Tlr7, Ccr9, and Cd83 in XCL1⁻ and XCL1⁺ CD8⁺ T cells in naive mice and in chronically-infected animals at day 9 p.i. Significant differences were determined by one-way ANOVA. ns, non-significant; ^*p ≤ 0.05; ^**p ≤ 0.01; ^****p ≤ 0.0001.