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Cholesterol-regulated mechanism of CD81. Cholesterol regulates CD81 equilibrium between the capped state (left) and the open state (right). The conformational transition between these states was studied with MD simulations, and it is believed to be an important regulatory step for the interactions between CD81 and other protein, such as CD19 (modeled in the picture).819 Reprinted with permission from ref (819). Copyright 2016 Elsevier Inc.
