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Proposed model of σB regulatory effect on S. aureus biofilm formation. The transcriptional regulator σB induces PNAG-independent biofilm formation by repressing extracellular proteases, by inhibiting nuclease secretion, and/or by the activation of Atl. On the other hand, σB regulates PNAG-dependent multicellular behavior by modulating PNAG levels by at least repressing IS256 and translationally regulating Ica enzymes.
