Table 4.
Cardiac Volume Analysis at Rest and Peak Exercise
| HFpEF (n=30) | HT (n=17) | Healthy (n=17) | P Value (Overall) | P Values for 2‐Way Comparisons if Overall Significant | |||
|---|---|---|---|---|---|---|---|
| HFpEF vs HT | HFpEF vs Healthy | HT vs Healthy | |||||
| LVEDV rest, mL | 91.6 (3.1) | 104.1 (5.0) | 90.5 (3.9) | 0.04 | 0.03 | 0.83 | 0.04 |
| LVEDV peak exercise, mL | 93.1 (3.3) | 111.5 (5.2) | 99.3 (4.0) | 0.008 | 0.003a | 0.24 | 0.07 |
| ΔLVEDV, mL | 1.5 (1.8) | 6.1 (2.4) | 8.8 (2.0) | 0.001 | 0.01a | 0.0006a | 0.38 |
| SV rest, mL | 59.5 (2.0) | 67.6 (3.1) | 59.3 (2.5) | 0.048 | 0.03 | 0.95 | 0.05 |
| SV peak exercise, mL | 63.5 (2.2) | 78.2 (3.7) | 70.0 (2.6) | 0.001 | 0.0007a | 0.06 | 0.08 |
| ΔSV, mL | 1.0 (1.4) | 9.6 (1.8) | 10.7 (1.7) | <0.0001 | <0.001a | <0.001a | 0.66 |
Values are mean (SEM). HFpEF indicates heart failure with preserved ejection fraction; HT, hypertensive controls; LVEDV, left ventricular end‐diastolic volume; SV, stroke volume; ΔLVEDV (mL), LVEDV peak exercise−LVEDV rest; ΔLVEDV, change in left ventricular end‐diastolic volume; ΔSV (mL), SV peak exercise−SV rest. ΔSV, change in stroke volume.
a
P (adjusted)≤0.017. Patients with HFpEF failed to increase end diastolic volume and therefore stroke volume with exercise, in contrast to hypertensive and healthy controls.