Figure 5.

Example with modified radii and number of segments used in the study of the effect of vessel dilation, constriction, and pruning on the permeability tensors. A, From left to right, increase by 10%, 20%, and 30% of vessel diameter of all microvessels that compose the microvasculature. B, 30% increase of vessel diameter applied to the 10%, 20%, and 30% of vessels. C, Decrease of vessel diameter of all microvessels. (D) Decrease of vessel diameter by percentage of microvessels: 10%, 20%, and 30% (from left to right). E, Pruning of 10%, 20%, and 30% of the capillaries with the smallest radius. The diagonal permeability tensor elements are provided Below each image. In parentheses, the percentages of decrease (negative sign) or increase (positive sign) with respect to the original values (ie, without any remodeling). Image corresponds to tissue from basal conditions. Some examples of remodeled vessels (B, D) or areas of pruned vessels (E) are highlighted in yellow circles.