Table 4.
Percentage of Change of the Permeability Tensor Diagonal Elements Based on Simulations of Different Vascular Remodeling Scenarios Using Tissue From Remote and Infarcted Areas 3 Days After MI
| Simulated condition | k11 | k22 | k33 |
|---|---|---|---|
| Dilation by 10% | |||
| R | 221.82±335.91% | 1256.52±3009.25% | 117.91±144.76% |
| I | 419.58±840.58% | 68.49±120.82% | 58.66±44.75% |
| Dilation by 20% | |||
| R | 855.61±1028.56% | 3227.07±7254.17% | 488.43±338.87% |
| I | 1572.26±2741.23% | 421.26±443.4% | 336.48±135.86% |
| Dilation by 30% | |||
| R | 2872.93±3431.13% | 9532.58±20954.24% | 1655.98±1017.35% |
| I | 6112.94±12142.87% | 1517.67±1443.88% | 1226.69±453.55% |
| 30% Increase of randomly selected vessels | |||
| Dilation of 10% of vessels | |||
| R | 134.28±246.51% | 896.56±2228% | 52.01±108.09% |
| I | 218.94±472.05% | 18.77±91.87% | 11.91±32.06% |
| Dilation of 20% of vessels | |||
| R | 269.19±381.23% | 1164.63±2778.21% | 130.21±144.09% |
| I | 474.79±767.15% | 84.38±160.85% | 77.33±57.51% |
| Dilation of 30% of vessels | |||
| R | 436.54±640.34% | 1386.63±3216.4% | 218.35±176.53% |
| I | 845.82±1444.27% | 147.62±201.8% | 158.14±99.19% |
| Constriction of all vessels | |||
| Constriction by 10% | |||
| R | 27.75±147.8% | 467.38±1278.1% | −14.86±62.32% |
| I | 73.61±252.64% | −42.78±34.87% | −37.42±19.62% |
| Constriction by 20% | |||
| R | −39.8±80.46% | 138.58±540.41% | −65.03±24.25% |
| I | −34±86.44% | −78.97±11.22% | −71.94±11.28% |
| Constriction by 30% | |||
| R | −92.17±11.82% | −70.31±67.61% | −95.79±3.16% |
| I | −92.6±9.76% | −97.7±1.28% | −96.11±2.24% |
| 20% Decrease in diameter of randomly selected vessels | |||
| Constriction of 10% of vessels | |||
| R | 99.25±233.9% | 795.81±2012.64% | 29.67±96.25% |
| I | 96.38±245.28% | −7.41±68% | −9.27±25.65% |
| Constriction of 20% of vessels | |||
| R | 158.53±327.89% | 836.69±2088.48% | 50.41±101.03% |
| I | 139.02±329.07% | −1.47±81.02% | 2.15±32.98% |
| Constriction of 30% of vessels | |||
| R | 148.25±356.85% | 510.46±1355.81% | 26.89±93.54% |
| I | 95.78±294.8% | −27.74±63.89% | −5.23±32.51% |
| Pruning of a percentage of the smallest microvessels | |||
| Pruning of 10% of vessels | |||
| R | 180.88±278.14% | 1221.15±2947.87% | 47.2±117.52% |
| I | 632.55±1843.79% | 61.6±172.81% | −3.25±31.72% |
| Pruning of 20% of vessels | |||
| R | 325.39±362.3% | 1274.65±2824.18% | 69.29±166.74% |
| I | 1419.43±3706.85% | 106.78±185.98% | 33.78±73.88% |
| Pruning of 30% of vessels | |||
| R | 513.62±598.17% | 1543.78±2669.19% | 985.77±2418.45% |
| I | 682.92±1779.71% | 22.19±141.59% | 45.01±68.76% |
Data shown as mean±SD of the percentage of change of the permeability tensor diagonal elements k 11, k 22, and k 33 based on simulations of different vascular remodeling scenarios using tissue from remote and infarcted areas 3 days after MI: (1) dilation of all microvessels comprising the microvasculature by incrementing their diameter by 10%, 20%, and 30%; (2) dilation of the 10%, 20%, and 30% of microvessels by increasing their diameter by 30%; (3) constriction of all microvessels comprising the microvasculature by incrementing their diameter by 10%, 20%, and 30%; (4) constriction of the 10%, 20%, and 30% of microvessels by decreasing their diameters by 20%; and (5) pruning of the 10%, 20%, and 30% of the smallest microvessels of the microvasculature. Rows marked with R and I correspond to results from remote areas and infarcted areas, respectively. MI indicates myocardial infarction.