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. 2019 Mar 23;8(7):e010860. doi: 10.1161/JAHA.118.010860

Figure 3.

Figure 3

Genetic deletion of TLR9 in Apoe −/− mice reduces inflammatory molecule expression in atherosclerotic plaques. A, Oil red O staining of atherosclerotic plaques in the aortic root. Lipid deposition in plaques was decreased in Tlr9 −/− Apoe −/− mice compared with that in Apoe −/− mice (n=11–16). Bar: 100 μm. B through D, Immunostaining against VCAM‐1 (B), ICAM‐1 (C), and Mac3 (D). Genetic deletion of TLR9 reduced the expression of adhesion molecules and accumulation of macrophages in atherosclerotic plaques in Apoe −/− mice (n=13–16). Bar: 100 μm. *P<0.05, **P<0.01, and ***P<0.001. All comparisons between Tlr9 −/− Apoe −/− mice and Apoe −/− mice were performed with unpaired Student t test. All values are mean±SEM. ICAM‐1 indicates intercellular cell adhesion molecule‐1; TLR9, Toll‐like receptor 9; VCAM‐1, vascular cell adhesion molecule‐1.